京都大学複合原子力科学研究所 放射線生命科学研究部門
粒子線生物学研究分野

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Recent Original Research Papers 近年の原著論文

■ 2020

  • Tano K, Nakano T, Shoulkamy MI, Tsuda M, Sasanuma H, Hirota K, Takata M, Masunaga S, Takeda S, Ide H, Bessho T. Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells. PLOS ONE (in press).
  • Yanagie H, Yanagawa M, Tiguchi T, Mizumachi R, Fujihara M, Morishita Y, Sakurai Y, Mouri K, Dewi N, Nonaka Y, Shinohara A, Matsukawa T, Kubota A, Yokoyama K, Suzuki M, Masunaga S,, Sakurai Y, Tanaka H, Ono K, Yamauchi H, Ono M, Nakajima J, Higashi S, Takahashi H. Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma. Appl. Radiat. Isot., 163, 2020, 109202, DOI: https://doi.org/10.1016/j.apradiso.2020.109202
  • Hu N, Tanaka H, Takata T, Endo S, Masunaga S, Suzuki M, Sakurai Y. Evaluation of PHITS for microdosimetry in BNCT to support radiobiological research. Appl. Radiat. Isot., 161, July 2020, 109148.

■ 2019

  • Masunaga S, Sakurai Y, Tanaka H, Takata T, Suzuki M, Sanada Y, Tano K, Maruhashi A and Ono K. Usefulness of combination with both continuous administration of hypoxic cytotoxin and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential. Int. J. Radiat. Biol., 95(12), 1708-1717, DOI: 10.1080/09553002.2019.1666214, Dec 2019.
  • Masunaga S, Tano K, Sanada Y, Suzuki M, Takahashi A, Ohnishi K and Ono K. Effects of p53 status of tumor cells and combined treatment with mild hyperthermia, wortmannin or caffeine on recovery from radiation-induced damage. World J. Oncol., 10(3), 132-141, DOI: 10.14740/wjon1203, June 2019.
  • Sato T, Masunaga S, Kumada H and Hamada N. Depth Distributions of RBE-Weighted Dose and Photon-Isoeffective Dose for Boron Neutron Capture Therapy. Radiat. Prot. Dosim., 183(1-2), 247-250, DOI: 10.1093/rpd/ncy235, May 2019.
  • Masunaga S, Sakurai Y, Tanaka H, Takata T, Suzuki M, Sanada Y, Tano K, Maruhashi A and Ono K. Effect of a change in reactor power on response of murine solid tumors in vivo, referring to impact on quiescent tumor cell population. Int. J. Radiat. Biol., 95(5), 635-645, DOI: 10.1080/09553002.2019.1558300, May 2019.
  • Isono A, Tsuji M, Sanada Y, Matsushita A, Masunaga S, Hirayama T and Nagasawa H. Design, synthesis, and evaluation of lipopeptide conjugates of mercaptoundecahydrododecaborate for boron neutron capture therapy. Chem Med Chem, 2019(14), 823-832, DOI: 10.1002/cmdc.201800793, Apr 2019.
  • Tanaka H, Takata T, Ishi Y, Uesugi T, Kuriyama Y, Watanabe T, Sakurai Y, Kawabata S, Masunaga S and Suzuki M. Development of proton beam irradiation system for small animals using FFAG accelerator. Nucl. Instrum. Methods Phys. Res. A, 922, 230-234, DOI: 10.1016/j.nima.2018.12.081, Apr 2019.
  • Kanemitsu T, Kawabata S, Fukumura M, Futamura G, Hiramatsu R, Nonoguchi N, Nakagawa F, Takata T, Tanaka H, Suzuki M, Masunaga S, Ono K, Miyatake S, Nakamura H and Kuroiwa T. Folate receptor-targeted novel boron compound for boron neutron capture therapy on F98 glioma-bearing rats. Radiat. Environ. Biophys., 58(1), 59-67, DOI: 10.1007/s00411-018-0765-2, Mar 2019.
  • Ono K, Tanaka H, Tamari Y, Watanabe T, Suzuki M and Masunaga S. Proposal for determining absolute biological effectiveness of boron neutron capture therapy—the effect of 10B(n,α)7Li dose can be predicted from the nucleocytoplasmic ratio or the cell size. J. Radiat. Res., 60(1), 29–36, DOI: 10.1093/jrr/rry080, Jan 2019.

■ 2018

  • Masunaga S, Kobayashi J, Tano K, Sanada Y, Suzuki M and Ono K. The Effect of p53 Status on Radio-Sensitivity of Quiescent Tumor Cell Population Irradiated With γ-Rays at Various Dose Rates. J. Clin. Med. Res., J. Dermatol.,10(11), 815-821, DOI: 10.14740/jocmr3610w, Nov 2018.
  • Tanaka H, Takata T, Sakurai Y, Kawabata S, Suzuki M, Masunaga S and Ono K. Development of real-time thermal neutron monitor array for boron neutron capture therapy. Ther. Radiol. Oncol., 2018(2), 51, DOI: 10.21037/tro.2018.10.10, Oct 2018.
  • Omori M, Fujiwara S, Shimizu H, Ikeda T, Bito T, Suzuki M, Masunaga S, Ono K and Nishigori C. Boron neutron capture therapy using reactor epithermal neutron beams could effectively control in-transit and lymph node metastases originating from a cutaneous malignant melanoma. J. Dermatol.,45(4), e90-e91, DOI: 10.1111/1346-8138.14134, Apr 2018.
  • Sato T, Masunaga S, Kumada H and Hamada N. Microdosimetric Modeling of Biological Effectiveness for Boron Neutron Capture Therapy Considering Intra- and Intercellular Heterogeneity in 10B Distribution. Sci. Rep., 8, Article number:988, DOI: 10.1038/s41598-017-18871-0, Jan 2018.
  • Sanada Y, Sasanuma H, Takeda S, Tano K and Masunaga S. Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma. Int. J. Rad. Biol., 94(1), 88-96, DOI: 10.1080/09553002.2018.1409443, Jan 2018.

■ 2017

  • Masunaga S, Tano K, Sanada Y, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Watanabe T, Takata T, Maruhashi A and Ono K. Effect of Tirapazamine, Metformin or Mild Hyperthermia on Recovery from Radiation-Induced Damage in Pimonidazole-Unlabeled Quiescent Tumor Cells. World J. Oncol., 8(5), 137-146, DOI: 10.14740/wjon1058w, Oct 2017.
  • Çağlayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC and Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Res., 45(17), 10079-10088, DOI: 10.1093/nar/gkx654, Sep 2017.
  • Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga S, Takeda S and Tano K. Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells. PLOS ONE, 12(9), e0185141, DOI: 10.1371/journal.pone.0185141, Sep 2017.
  • Yanagie H, Dewi N, Higashi S, Ikushima I, Seguchi K, Mizumachi R, Murata Y, Morishita Y, Shinohara A, Mikado S, Yasuda N, Fujihara M, Sakurai Y, Mouri K, Yanagawa M, Iizuka T, Suzuki M, Sakurai Y, Masunaga S, Tanaka H, Matsukawa T, Yokoyama K, Fujino T, Ogura K, Nonaka Y, Sugiyama H, Kajiyama T, Yui S, Nishimura R, Ono K,Takamoto S, Nakajima J, Ono M, Eriguchi M, Hasumi K and Takahashi H. Selective Boron Delivery by Intra-arterial Injection of BSH-WOW Emulsion in Hepatic Cancer Model for Neutron Capture Therapy. Br. J. Radiol., 90(1074), 20170004, DOI: 10.1259/bjr.20170004, May 2017.
  • Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga S and Tano K. Cytotoxicity of tirapazamine (3-amino-1, 2, 4-benzotriazine-1, 4-dioxide)-induced DNA damage in chicken DT40 cells. Chem. Res. Toxicol., 30(2), 699-704, DOI: 10.1021/acs.chemrestox.6b00417, Feb 2017.
  • Tanaka H, Sakurai Y, Takata T, Watanabe T, Kawabata S, Suzuki M, Masunaga S, Taki K, Akabori K, Watanabe K and Ono K. NOTE: Development of real-time epithermal neutron detector for boron neutron capture therapy. Rev. Sci. Inst., 88(5), 056101, DOI: 10.1063/1.4982036, May 2017.
  • Futamura G, Kawabata S, Nonoguchi N, Hiramatsu R, Toho T, Tanaka H, Masunaga S, Hattori Y, Kirihata M, Ono K, Kuroiwa T and Miyatake S. Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma. Radiat. Oncol., 12, 26(1-11), DOI: 10.1186/s13014-017-0765-4, Jan 2017.

■ 2016

  • Watanabe T, Hattori Y, Ohta Y, Ishimura M, Nakagawa Y, Sanada Y, Tanaka H, Fukutani S, Masunaga S, Hiraoka M, Ono K, Suzuki M and Kirihata M. Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy. BMC Cancer, 16:859, DOI: 10.1186/s12885-016-2913-x, Nov 2016.
  • Kondo N, Michiue H, Sakurai Y, Tanaka H, Nakagawa Y, Watanabe T, Narabayashi M, Kinashi Y, Suzuki M, Masunaga S and Ono K. Detection of γH2AX foci in mouse normal brain and brain tumor after boron neutron capture therapy. Rep. Prac. Oncol. Radiother., 21(2), 108-112, March-April 2016.
  • Kondo N, Sakurai Y, Hirota Y, Tanaka H, Watanabe T, Nakagawa Y, Narabayashi M, Kinashi Y, Miyatake S, Hasegawa M, Suzuki M, Masunaga S, Ohnishi T and Ono K. DNA damage induced by boron neutron capture therapy is partially repaired by DNA ligase IV. Radiat. Environ. Biophys., 55(1), 89-94, Mar 2016.
  • Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Moriwaki T, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A and Ono K. Effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of 10B-carriers. Int. J. Rad. Biol., 92(4), 187-194, Feb 2016.

■ 2015

  • Sato A, Itoh T, Imamichi S, Kikuhara S, Fujimori H, Hirai T, Saito S, Sakurai Y, Tanaka H, Nakamura H, Suzuki M, Murakami Y, Baiseitov D, Berikkhanova K, Zhumadilov Z, Imahori Y, Itami J, Ono K, Masunaga S and Masutani M. Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells. Appl. Radiat. Isot., 106, 213-219, Dec 2015.
  • Fujimoto N, Tanaka H, Sakurai Y, Takata T, Kondo N, Narabayashi M, Nakagawa Y, Watanabe T, Kinashi Y, Masunaga S, Maruhashi A, Ono, K and Suzuki M. Improvement of depth dose distribution using multiple-field irradiation in boron neutron capture therapy.Appl. Radiat. Isot., 106, 134-138, Dec 2015.
  • Kondo N, Sakurai Y, Takata T, Takai N, Nakagawa Y, Tanaka H, Watanabe T, Kume K,? Toho T, Miyatake S, Suzuki M, Masunaga S and Ono K. Localized radiation necrosis model in mouse brain using proton ion beams. Appl. Radiat. Isot., 106, 242-246, Dec 2015.
  • Sakurai Y, Tanaka H, Kondo N, Kinashi Y, Suzuki M, Masunaga S, Ono K and Maruhashi A. Development of a dual phantom technique for measuring the fast neutron component of dose in boron neutron capture therapy. Med. Phys., 42(11), 6651-7, Noc 2015.
  • Masunaga S, Uzawa A, Hirayama R, Matsumoto Y, Sakurai Y, Tanaka H, Tano K, Sanada Y, Suzuki M, Maruhashi A and Ono K. The effect of p53 status of tumor cells on radiosensitivity of irradiated tumors with carbon-ion beams compared with γ-rays or reactor neutron beams. World J. Oncol., 6(4), 398-409, Aug 2015.
  • Sakurai Y, Tanaka H, Takata T, Fujimoto N, Suzuki M, Masunaga S, Kinashi Y, Kondo N, Narabayashi M, Nakagawa Y, Watanabe T, Ono K and Maruhashi A. Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT. J. Korean Phys. Soc., 67(1), 76-81, Jul 2015.

■ 2014

  • Hattori Y, Kusaka S, Mukumoto M, Ishimura M, Ohta Y, Takenaka H, Uehara K, Asano T, Suzuki M, Masunaga S, Ono K, Tanimori S and Kirihata M. Synthesis and in vitro evaluation of thiododecaborated α, α-cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy. Amino Acids, 46(12), 2715-2720, Dec 2014.
  • Masunaga S, Sanada Y, Moriwaki T, Tano K, Sakurai Y, Tanaka H, SuzukiM, Kondo N, Narabayashi M, Watanabe T, Nakagawa Y, Maruhashi A and Ono K. Significance of Fractionated Administration of Thalidomide Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis. World J. Oncol., 5(4), 155-165, Aug 2014.
  • Sanada Y, Asai S, Ikemoto A, Moriwaki T, Nakamura N, Miyaji M and Zhang-Akiyama QM. Oxidation resistance 1 is essential for protection against oxidative stress and participates in the regulation of aging in Caenorhabditis elegans. Free Radic. Res., 48(8), 919-928, Aug 2014.
  • Tada R, Uto Y, Masunaga S, Kinashi Y, Ono K and Hori H. An NDT Study of a Boron Tracedrug UTX-51 for Glycated BSA as an AGE Model. Anticancer Res., 34(8), 4503-4507, Aug 2014.
  • Okamoto S, Narita T, Sasanuma H, Takeda S, Masunaga S, Bessho T and Tano K. Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines. Genes Cancer, 5(7-8), 285-292, Jul 2014.
  • Masunaga S, Sakurai Y, Tano K, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Nakagawa Y, Maruhashi A and Ono K. Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis. Exp. Ther. Med., 8(1), 291-301, Jul 2014.
  • Iwagami T, Ishikawa Y, Koshizaki N, Yamamoto N, Tanaka H, Masunaga S, Sakurai Y, Kato I, Iwai S, Suzuki M and Yura Y. Boron carbide particle as a boron compound for boron neutron capture therapy. J. Nucl. Med. Radiat. Ther., 5(2), 177, June 2014.
  • Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Mitsumoto T, Kinashi Y, Kondo N, Narabayashi M, Nakagawa Y, Watanabe T, Fujimoto N, Maruhashi A and Ono K. Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography. Appl. Radiat. Isot., 88, 153-156, Jun 2014.
  • Sakurai Y, Tanaka H, Suzuki M, Masunaga S, Kinashi Y, Kondo N, Ono K and Maruhashi A. Dose estimation for internal organs during boron neutron capture therapy for body-trunk tumors. Appl. Radiat. Isot., 88, 43-45, Jun 2014.
  • Yanagie H, Higashi S, Seguchi K, Ikushima I, Fujihara M, Nonaka Y, Oyama K, Maruyama S, Hatae R, Suzuki M, Masunaga S, Kinashi T, Sakurai Y, Tanaka H, Kondo N, Narabayashi M, Kajiyama T, Maruhashi A, Ono K, Nakajima J, Ono M, Takahashi H and Eriguchi M. Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a 10BSH-containing WOW emulsion. Appl. Radiat. Isot., 88,32-37, Jun 2014.
  • Masunaga S, Sakurai Y, Tanaka H, Tano K, Suzuki M, Kondo N, Narabayashi M, Nakagawa Y, Watanabe T, Maruhashi A and Ono K. The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy. SpringerPlus, 3, 128(1-11), Mar 2014.
  • Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Takamiya K, Maruhashi A and Ono K. Development of a simple and rapid method of precisely identifying the position of 10B atoms in tissue: an improvement in standard alpha autoradiography. J. Radiat. Res., 55(2), 373-380, Mar 2014.
  • Sanada Y and Zhang-Akiyama QM. An increase of oxidized nucleotides activates DNA damage checkpoint pathway that regulates post-embryonic development in Caenorhabditis elegans. Mutagenesis, 29(2), 107-114, Feb 2014.
  • Hirota Y, Masunaga S, Kondo N, Kawabata S, Hirakawa H, Yajima H, Fujimori A, Ono K, Kuroiwa T and Miyatake S. High linear-energy-transfer radiation can overcome radioresistance of glioma stem-like cells to low linear-energy-transfer radiation. J. Radiat. Res., 55(1), 75-83, Jan 2014.
  • Suzuki M, Kato I, Aihara T, Hiratsuka J, Yoshimura K, Niimi M, Kimura Y, Ariyoshi Y, Haginomori S, Sakurai Y, Kinashi Y, Masunaga S, Fukushima M, Ono K and Maruhashi A. Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer. J. Radiat. Res., 55(1), 146-153, Jan 2014.

■ 2013

  • Yamamoto N, Iwagami T, Kato I, Masunaga S, Sakurai Y, Iwai S, Nakazawa M, Ono K and Yura Y. Sonoporation as an enhancing method for boron neutron capture therapy for squamous cell carcinomas. Radiat. Oncol., 8, 280(1-7), Dec 2013.
  • Hirayama R, Uzawa A, Takase N, Matsumoto Y, Noguchi M, Koda K, Ozaki M, Yamashita K, Li H, Kase Y, Matsufuji N, Koike S, Masunaga S, Ando K, Okayasu R and Furusawa Y. Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays. Mutat. Res.-Gen. Tox. En., 756(1-2), 146-151, Aug 2013.
  • Kashino G, Tamari Y, Kumagai J, Tano K and Watanabe M. Suppressive effect of ascorbic acid on the mutagenesis induced by the bystander effect through mitochondrial function. Free Radic. Res., 47(6-7), 474-479, Jul 2013.
  • Masaoka A, Gassman NR, Horton JK, Kedar PS, Witt KL, Hobbs CA, Kissling GE, Tano K, Asagoshi K and Wilson SH. Interaction between DNA Polymerase β and BRCA1. PLOS ONE, 8(6), e66801(1-11), Jun 2013.
  • Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Tano K, Maruhashi A and Ono K. Effect of tirapazamine and mild temperature hyperthermia on the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population. J. Canc. Ther., 4(2), 521-528, Apr 2013.
  • Liu Y, Suzuki M, Masunaga S, Chen YW, Kashino G, Tanaka H, Sakurai Y, Kirihata M and Ono K. Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor. J. Radiat. Res., 54(2), 260-267, Mar 2013.
  • Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Maruhashi A and Ono K. Wortmannin efficiently suppresses the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population. J. Radiat. Res., 54(2), 221-229, Mar 2013.
  • Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Tano K, Maruhashi A and Ono K. Usefulness of daily fractionated administration of wortmannin combined with γ-ray irradiation in terms of local tumor response and lung metastasis. World J. Oncol., 4(1), 26-36, Feb 2013.
  • Masunaga S, Sakurai Y, Tanaka H, Hirayama R, Matsumoto Y, Uzawa A, Suzuki M, Kondo N, Narabayashi M, Maruhashi A and Ono K. Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to γ-rays, accelerated carbon ion beams and boron neutron capture reaction. Br. J. Radiol., 86(1021), 20120302(1-10), Jan 2013.
  • Tamari Y, Nawata H, Inoue E, Yoshimura A, Yoshii H, Kashino G, Seki M, Enomoto T, Watanabe M and Tano K. Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. Free Radic. Res., 47(1), 1-7, Jan 2013.

■ 2012

  • Sanada U, Yonekura S, kikuchi M, Hashiguchi K, Nakamura N, Yonei S and Zhang-Akiyama QM. NDX-1 protein hydrolyzes 8-oxo-7,8- dihydrodeoxyguanosine-5'-diphosphate to sanitize oxidized nucleotides and prevent oxidative stress in Caenorhabditis elegans. J. biochem., 150(6), 649-657, Dec 2011.
  • Masunaga S, Liu Y, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Masuhashi A and Ono K. Usefulness of combined treatment with continuous administration of tirapazamine and mild temperature hyperthermia in γ-ray irradiation in terms of local tumor response and lung metastatic potential. Int. J. Hyperthermia, 28(7), 636-644, Nov 2012.
  • Hattori Y, Kusaka S, Mukumoto M, Uehara K, Asano T, Suzuki M, Masunaga S, Ono K, Tanimori S and Kirihata M. Biological Evaluation of Dodecaborate-Containing L-Amino Acids for Boron Neutron Capture Therapy. J. Med. Chem., 55(15), 6980-6984, Aug 2012.
  • Masunaga S, Kimura S, Harada T, Okuda K, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A, Nagasawa H and Ono K. Evaluating the usefulness of a novel 10B-carrier conjugated with cyclic RGD peptide in boron neutron capture therapy. World J. Oncol., 3(3), 103-112, Jun 2012.
  • Suzuki M, Suzuki O, Sakurai Y, Tanaka H, Kondo N, Kinashi Y, Masunaga S, Maruhashi A and Ono K. Reirradiation for locally recurrent lung cancer in the chest wall with boron neutron capture therapy (BNCT). Int. Canc. Conf. J., 1(4), 235-238, Mar 2012.
  • Masunaga S, Sakurai Y, Tanaka H, Suzuki M, Liu Y, Kondo N, Maruhashi A, Kinashi Y and Ono K. Effects of employing a 10B-carrier and manipulating intratumor hypoxia on local tumor response and lung metastatic potential in boron neutron capture therapy. Br. J. Radiol., 85(1011), 249-258, Mar 2012.
  • Nishiura H, Kumagai J, Kashino G, Okada T, Tano K and Watanabe M. The bystander effect is a novel mechanism of UVA-induced melanogenesis. Photochem. Photobiol., 88(2), 389-397, Mar 2012.
  • Okada T, Kashino G, Nishiura H, Tano K and Watanabe M. Micronuclei Formation Induced by X-Ray Irradiation Does Not Always Result from DNA Double-strand Breaks. J. Radiat. Res., 53(1), 93-100, Feb 2012.

■ 2011

  • Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Mitsumoto T, Fujita K, Kashino G, Kinashi Y, Liu Y, Takada M, Ono K and Maruhashi A. Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-BENS). Appl. Radiat. Isot., 69(12), 1642-1645, Dec 2011.
  • Masunaga S, Liu Y, Tanaka H, Sakurai Y, Suzuki M, Kondo N, Maruhashi A and Ono K. Reducing intratumour acute hypoxia through bevacizumab treatment, referring to the response of quiescent tumor cells and metastatic potential. Br. J. Radiol., 84(1008), 1131-1138, Dec 2011.
  • Kinashi Y, Takahashi S, Kashino G, Okayasu R, Masunaga S, Suzuki M and Ono K. DNA double-strand break induction in Ku80-deficient CHO cells following Boron Neutron Capture Reaction. Radiat. Oncol., 6, 106(1-8), Sep 2011.
  • Nawata H, Kashino G, Tano K, Daino K, Shimada Y, Kugoh H, Oshimura M and Watanabe M. Dysregulation of Gene Expression in the Artificial Human Trisomy Cells of Chromosome 8 Associated with Transformed Cell Phenotypes. PLoS One, 6(9), e25319, Sep 2011.
  • Kondo N, Takahashi A, Mori E, Noda T, Zdzienicka MZ, Thompson LH, Helleday T, Suzuki M, Kinashi Y, Masunaga S, Ono K, Hasegawa M and Ohnishi T. FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One, 6(5), e19659, May 2011.
  • Kimura S, Masunaga S, Harada T, Kawamura Y, Ueda S, Okuda K and Nagasawa H. Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy. Bioorgan. Med. Chem., 19(5), 1721-1728, Mar 2011.
  • Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E and Hori H. Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo. J. Radiat. Res., 52(2), 208-214, Mar 2011.
  • Masunaga S, Liu Y, Tanaka H, Sakurai Y, Suzuki M, Kondo N, Maruhashi A and Ono K. Radiosensitivity and capacity to recover from radiation-induced damage in pimonidazole-unlabeled intratumor quiescent cells depend on p53 status. World J. Oncol., 2(1), 1-9, Feb 2011.

■ 2010

  • Yonekura S, Sanada U and Zhang-Akiyama QM. CiMutT, an asidian MutT homologue, has a 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase activity responsible for sanitization of oxidized nucleotides in Ciona intestinalis. Genes Genet. Syst., 85(4), 287-295, Dec 2010.
  • Kashino G, Liu Y, Suzuki M, Masunaga S, Kinashi Y, Ono K, Tano K and Watanabe M. An Alternative Mechanism for Radioprotection by Dimethyl Sulfoxide; Possible Facilitation of DNA Double-strand Break Repair. J. Radiat. Res., 51(6), 733-740, Nov 2010.
  • Masunaga S, Nagasawa H, Liu Y, Sakurai Y, Tanaka H, Kashino G, Suzuki M, Kinashi Y and Ono K. Evaluation of the Radiosensitivity of the Oxygenated Tumor Cell Fractions in Quiescent Cell Populations within Solid Tumors. Radiat. Res., 174(4), 459-466, Oct 2010.
  • Masunaga S, Matsumoto Y, Kashino G, Hirayama R, Liu Y, Tanaka H, Sakurai Y, Suzuki M, Kinashi Y, Maruhashi A and Ono K. Significance of manipulating tumor hypoxia and radiation dose rate in terms of local tumor response and lung metastatic potential, referring to the response of quiescent cell populations. Br. J. Radiol., 83(993), 776-784, Sep 2010.
  • Inoue E, Tano K, Yoshii H, Nakamura J, Tada S, Watanabe M, Seki M and Enomoto T. SOD1 is Essential for the Viability of DT40 Cells and Nuclear SOD1 Functions as a Guardian of Genomic DNA. J. Nucleic Acids, 2010, 795946, Aug 2010.
  • Hamada N, Imaoka T, Masunaga S, Ogata T, Okayasu R, Takahashi A, Kato TA, Kobayashi Y, Ohnishi T, Ono K, Shimada Y and Teshima T. Recent advances in the biology of heavy-ion cancer therapy. J. Radiat. Res., 51(4), 365-383, Jul 2010.
  • Masunaga S, Hirayama R, Uzawa A, Kashinio G, Takata T, Tanaka H, Suzuki M, Kinashi Y, Liu Y, Koike S, Ando K and Ono K. Influence of Manipulating Hypoxia in Solid Tumors on the Radiation Dose-Rate Effect in vivo, with Reference to that in the Quiescent cell Population. Jpn. J. Radiol., 28(2), 132-142, Feb 2010.
  • Asagoshi K, Tano K, Chastain PD II, Adachi N, Sonoda E, Kikuchi K, Koyama H, Nagata K, Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA and Nakamura J. FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells. Mol. Cancer Res., 8(2), 204-215, Feb 2010.
  • Kinashi Y, Tanaka H, Masunaga S, Suzuki M, Kashino G, Liu Y, Takahashi S and Ono K. Ascobic acid 2-glucocide reduces micronucleus induction in distant splenic T lymphocytes following head irradiation. Mutat. Res.-Gen. Tox. En., 695(1-2), 69-74, Jan 2010.
  • Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Suzuki M, Kinashi Y and Ono K. Adverse effect of mild temperature hyperthermia combined with hexamethylenetetramine compared to its effect combined with tirapazamine in the treatment of solid tumors. Exp. Ther. Med., 1(1), 169-174, Jan-Feb 2010.
  • Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Takahashi A, Tanaka H, Suzuki M, Ohnishi K, Kinashi Y, Liu Y, Ohnishi T and Ono K. Usefulness of hexamethylenetetramine as an adjuvant to radiation and cisplatin in the treatment of solid tumors: its independency of p53 status. J. Radiat. Res., 51(1), 27-35, Jan 2010.

Recent Books 近年の書籍

  • 増永慎一郎,分割照射の基礎,『がん・放射線療法 2017』,学研メディカル秀潤社,2017年6月
  • Masunaga S, Tumor Microenvironment and Hyperthermia. In "Hyperthermic Oncology from Bench to Bedside" PartII Basic Science in Whole Body, Springer, Jun 2016.
  • 増永慎一郎,放射線治療中でも普通に生活できますか?がん放射線治療のしくみについておしえてください。放射線治療は、なぜがんに有効なのですか?,『患者さんと家族のための放射線治療Q&A 2015年版』,金原出版,2015年11月
  • 増永慎一郎,1-2 治療抵抗性腫瘍細胞の放射線増感,『新しい酵素標的・増感放射線療法 KORTUCの基礎と臨床』,篠原出版新社,2015年3月
  • 増永慎一郎,2-6① 放射線生物学,『チームで取り組む 乳がん放射線療法』,メディカル教育研究社,2013年9月
  • 増永慎一郎,2-B がん細胞と正常組織の放射線応答,『臨床放射線腫瘍学―最新知見に基づいた放射線治療の実践』,南江堂,2012年12月
  • 小野公二, 鈴木実, 増永慎一郎, I-Q11 中性子捕捉療法,『がん治療レクチャー 2-1 これだけは知っておきたい!放射線療法 Q&A ―基本知識と最前線―』,総合医学社,2011年3月
  • 増永慎一郎,3-6 分割照射の基礎,『がん・放射線療法 2010』,篠原出版新社,2010年11月

Recent Reviews 近年の総説等

  • Shin-ichiro Masunaga , Yu Sanada, Keizo Tano, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki and Koji Ono, An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness, J. Radiat. Res., in press.
  • Kobashikawa S, Sakaguchi Y, Masunaga S, Mori E. Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression. Thermal Medicine, 35(4): 41-58, 2019. DOI https://doi.org/10.3191/thermalmed.35.41
  • 増永慎一郎,鈴木実,田野恵三,真田悠生,小野公二,「治療生物学的および放射線治療医的視点から見た中性子捕捉療法の特性」,日本口腔腫瘍学会誌,28(3),134-147,Sep 2016.
  • 真田悠生,森脇隆仁,田野恵三,増永慎一郎,「腫瘍内環境とがん細胞増感の試み」, 放射線生物研究, 50(2), 148-172, Jun 2015.
  • 増永慎一郎,「腫瘍生物学的視点から」,Radioisotopes, 64(1), 69-79, Jan 2015.
  • 増永慎一郎,「放射線生物学の今」,JASTRO NEWSLETTER, 112, 38, 2014.
  • 増永慎一郎,「放射線感受性を修飾する内因性および外因性因子」,JASTRO NEWSLETTER, 112, 42-44, 2014.
  • 宮路将弘, 松井亜子, 山崎晃, 真田悠生, 秋山(張)秋梅, 「酸化ストレス防御タンパク質OXR1の突然変異、神経疾患への関わり」, 放射線生物研究, 49(2), 111-125, Jun 2014.
  • 松本孔貴, 増永慎一郎, 皆巳和賢, 鷲山幸信, 尾方俊至, 手島昭樹, 松浦成昭, 古澤佳也,「放射線治療に資するがん転移研究―オーバービュー―」, 癌の臨床, 59(2), 141-148, Apr 2013.
  • 増永慎一郎, 松本孔貴, 平山亮一, 櫻井良憲, 田中浩基, 鵜澤玲子, 鈴木実, 近藤夏子, 楢林正流, 丸橋晃, 小野公二, 「通常放射線照射および中性子捕捉療法後の局所腫瘍効果と肺転移抑制効果における腫瘍内酸素状況修飾処置併用の意義」, 癌の臨床, 59(2), 149-153, Apr 2013.
  • 小野公二,鈴木実,増永慎一郎,近藤夏子,櫻井良憲,田中浩基,木梨友子,丸橋晃,「ホウ素中性子捕捉療法」,Radioisotopes, 61(4), 209-222, Dec 2012.
  • 増永慎一郎, 小川恭弘, 「放射線治療効果の修飾因子について」, 癌の臨床, 57(6), 265-270, Dec 2011.
  • 増永慎一郎, 「医師の立場-放射線治療医の視点から」:(特集)岐路に立つホウ素中性子捕捉療法, エネルギーレビュー, 31(11), Nov 2011.
  • 小野公二, 鈴木実, 増永慎一郎, 劉勇, 近藤夏子, 木梨友子, 菓子野元郎, 櫻井良憲, 田中浩基, 丸橋晃, 「加速器中性子源によるホウ素中性子捕捉療法の展望」, 映像情報メディカル, 42(11), 1038-1041, Nov 2010.
  • 真田悠生, 加藤悠一, 森脇隆仁, 橋口一成, 秋山(張)秋梅, 「線虫C. elegansにおける酸化DNAの修復」, 放射線生物研究, 45(3), 286-302, Sep 2010.
  • 増永慎一郎, 櫻井良憲, 菓子野元郎, 鈴木実, 田中浩基, 劉勇, 近藤夏子, 木梨友子, 平山亮一, 松本孔貴, 鵜澤玲子, 小池幸子, 安藤興一, 丸橋晃, 小野公二, 「休止期腫瘍細胞の挙動から見た分割照射」, 癌の臨床, 56(6), 451-456, Jun 2010.