Publications

2020

  1. Age-related isomerization of Asp in human immunoglobulin G kappa chain.
    Ha S, Kinouchi T and Fujii N. Biochimica et Biophysica Acta -Proteins and Proteomics, 1868, 140410 (publish on line)(2020).


2019

  1. A single Asp isomer substitution in an αA-crystallin-derived peptide induces a large change in peptide properties.
    Magami K, Kim I and Fujii N. Exp Eye Res. Accepted (2019).


  1. Site-Specific Rapid Deamidation and Isomerization in Human Lens αA-crystallin in vitro.
    Takata T, Ha S, Koide T and Fujii N. Protein science. in press (2019).


  1. Negative Charge at Aspartate 151 is Important for Human Lens αA-crystallin Stability and Chaperone Function.
    Takata T, Toshiya M, Nakamura-Hirota T and Fujii N. Exp Eye Res. 182, 10-18 (2019).

2018

  1. Asp58 modulates lens αA-crystallin oligomer formation and chaperone function.
    Takata T, Nakamura-Hirota T, Inoue R, Morishima K, Sato N, Sugiyama M and Fujii N. FEBS J. 285, 2263-2277 (2018).

  2. Identification of Isomeric Aspartate residues in βB2-crystallin from Aged Human Lens.

    Takata T, Murakami K, Toyama A and Fujii N. Biochimica et Biophysica Acta -Proteins and Proteomics, 1866, 767-774
    (2018).


2017

  1. Identification of ᴅ-amino acid-containing peptides in human serum.
    Ha S, Kim I, Takata T, Kinouchi T,  Isoyama M, Suzuki M, Fujii N.  PLoS ONE 12(12): e0189972. (2017).


  1. Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide.
    Nagai N, Kotani S, Mano Y, Ueno A, Ito Y, Kitaba T, Takata T and Fujii N. Biomed Res Int, 2017:5343010. (2017).


  1. Isomeric replacement of a single aspartic acid induces a marked change in protein function: the example of ribonuclease A.

   Sakaue H, Kinouchi T, Fujii N, Takata T and Fujii N. ACS Omega. 2, 260-267 (2017). 


2016

  1. One-shot LC-MS/MS analysis of post-translational modifications including oxidation and deamidation of rat lens α- and β-crystallins induced by γ-irradiation.
    Kim I, Saito T, Fujii N, Kanamoto T and Fujii N. Amino Acids. 48, 2855-2866 (2016). 

  2. Aggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract.
    Serebryany E, Takata T, Erickson E, Schafheimer N, Wang Y, King JA. Protein science. 6, 1115-1128 (2016).

  3. New insight into the dynamical system of αB-crystallin oligomers.
    Inoue R, Takata T, Fujii N, Ishii K, Uchiyama S, Sato N, Oba Y, Wood K, Kato K, Fujii N and Sugiyama M. Scientific Reports. 6, 29208 (2016).

  4. Isomerization of Asp residues plays an important role in αA-crystallin dissociation.
    Takata T and Fujii N. FEBS J. 283, 850-859 (2016).

2015

  1. Site specific oxidation of amino acid residues in rat lens γ-crystallin induced by low doseγ-irradiation.
    Kim I, Saito T, Fujii N, Kanamoto T, Chatake T and Fujii N. Biochemical and Biophysical Research Communications 466, 622-628 (2015).

  2. Effect of Asp 96 isomerization on the properties of a lens αB-crystallin-derived short peptide.
    Takata T and Fujii N. J Pharm Biomed Anal. 116, 139-144 (2015).

  3. Immunohistochemical localization of D-β-aspartic acid-containing proteins in pterygium.
    Kaji Y, Oshika T, Nejima R, Mori S, Miyata K, Fujii N. J Pharm Biomed Anal. 116, 86-89 (2015).

  4. Interaction of αA-crystallin F71L mutant with wild type αA- and αB-crystallins by mammalian two hybrid assay.
    Ramkumar S, Thankappan B, Fujii N, Natarajaseenivasan K, Anbarasu K. Int J Biol Macromol. 76, 102-108 (2015).

  5. Real-time heterogeneous protein-protein interaction between αA-crystallin N-terminal mutants and αB-crystallin using quartz crystal microbalance (QCM).
    Ramkumar S, Fujii N, Sakaue H, Fujii N, Thankappan B, Kumari RP, Natarajaseenivasan K, Anbarasu K. Amino Acids. 47, 1035-1043 (2015).

  6. Rapid Survey of Four Asp Isomers in Disease-Related Proteins by LC-MS combined with Commercial Enzyme.
    Maeda H, Takata T,Fujii N,Sakaue H, Nirasawa S, Takahashi S, Sasaki H and Fujii N. Anal. Chem. 87, 561-568 (2015).

  7. αB- and βA3-crystallins containing D-Aspartic acids exist in a monomeri c state.
    Sakaue H, Takata T, Fujii N, Sasaki, H and Fujii N Biochimica et Biophysica Acta -Proteins and Proteomics. 1854, 1-9 (2015).


2014

  1. In vitro Amyloidogenic Peptides of Galectin-7: Possible Mechanism of Amyloidogenesis of Primary Localized Cutaneous Amyloidosis.
    Ono K, Fujimoto E, Fujimoto N, Akiyama M, Satoh T, Maeda H, Fujii N, Tajima S. J Biol Chem. 289, 29195-29207 (2014).

  2. Comparison of effect of gamma ray irradiation on wild-type and N-terminal mutants of αA-crystallin.
    Ramkumar S, Fujii N, Fujii N, Thankappan B, Sakaue H, Ingu K, Natarajaseenivasan K, Anbarasu K. Mol Vis. 20:1002-1016 (2014).

  3. Three cases of elastofibroma with immunohistochemical analysis of microfibrillar components.
    Uehara M, Matsuda K, Kato A, Sato S , Shimizu F, Ooatari1 M, Kai Y, Shimada H, Hatano Y, Okamoto O, Katagiri K, Sasaki T, Fujii N, Fujiwara S. Eur J Dermatol (2014).

  4. Effects of carotenoids on damage of biological lipids induced by gamma irradiation.
    Saito T. and Fujii N. Radiat. Phys. Chem. 98, 57-63 (2014).

2013

  1. Simultaneous ultraviolet-B induced photo-oxidation of tryptophan/tyrosine and racemization of neighboring aspartyl residues in peptides.
    Cai S, Fujii N, Saito T, and Fujii N. Free Radical Biology & Medicine 65, 1037-1046 (2013).

  2. Antimicrobial and Antibiofilm Activity of Designed and Synthesized Antimicrobial Peptide, KABT-AMP.
    Thankappan B, Jeyarajan S, Sakaue H, Anbarasu K, Natarajaseenivasan K. & Fujii N. Appl Biochem Biotechnol. 170, 1184-1193 (2013).

  3. Galectin-7 and actin are components of amyloid deposit of localized cutaneous amyloidosis.
    Miura, Yoshinori; Harumiya, Satoru; Ono, Koji; Fujimoto, Eita; Akiyama, Minoru; Fujii, Noriko; Kawano, Hiroo; Wachi, Hiroshi; Tajima, Shingo. Experimental Dermatology 22, 36-40 (2013).

  4. Kinetics of isomerization and inversion of aspartate 58 of αA-crystallin peptide mimics under physiological conditions.
    Kenzo Aki, Norihiko Fuji and Noriko Fujii. PLoS One. 8 (3):e58515. (2013).

2012

  1. A rapid comprehensive LC-MS based survey of the Asp isomers in crystallins from human cataract lenses.
    Fujii N, Sakaue H. Sasaki H. and *Fujii N. J. Biol Chem. VOL.287, NO.47, PP.39992-40002, (2012).

  2. Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice.
    Tamura H, Ohgami N, Yajima I, Iida M, Ohgami K, Fujii N, Itabe H, Kusudo T, Yamashita H, Kato M. PLoS One. 7 (6):e39807. (2012).

  3. A P39R mutation at the N-terminal domain of human αB-crystallin regulates its oligomeric state and chaperone-like activity.
    Numoto N, Kita A, Fujii N, Miki K., Biochem Biophys Res Commun.,425,:601-606 (2012).

  4. Co-localisation of advanced glycation end products and D-β-aspartic acid-containing proteins in gelatinous drop-like corneal dystrophy.
    Kaji Y, Oshika T, Takazawa Y, Fukayama M, Fujii N., Br J Ophthalmol, 96(8):1127-31. (2012).

  5. Structural features of isomerizable aspartyl residues in human α-crystallins.
    Ken-ichi Shimizu, Akiko Kita, Noriko Fujii, and Kunio Miki, Molecular Vision, 18, 1823-1827 (2012).

  6. Characterization of an antibody that recognizes peptides containing D-β-aspartyl residues.
    Kenzo Aki, Norihiko Fujii, Takeshi Saito and Noriko Fujii, Molecular Vision, 18,996-1003(2012).

2011

  1. Characterization and Radio-resistant Function of Manganese Superoxide Dismutase of Rubrobacter radiotolerans.
    H. Terato, K. Suzuki, N. Nishioka, A. Okamoto, Y. Shimazaki-Tokuyama, Y. Inoue and T. Saito J. Radiat. Res. 22, 735-742. (2011).

  2. Simultaneous stereoinversion and isomerization at the Asp-4 residue in βB2-crystallin from the aged human eye lenses.
    Norihiko Fujii, Takeshi Kawaguchi, Hiroshi Sasaki and Noriko Fujii. Biochemistry 50, 8628-8635 (2011).

  3. UV B-irradiation enhances the racemization and isomerizaiton of aspartyl residues and production of Nε-carboxymethyl lysine (CML) in keratin of skin.
    Yuhei Mori, Kenzo Aki, Katsunori Kuge, Natsuko Yamanaka, Shingo Tajima, Yuichi Kaji, Ryoji Nagai, Hanako Yoshii, Naoki Yamamoto, Norihiko Fujii, Masami Watanabe, Tadatoshi Kinouchi and Noriko Fujii. J. Chromatogr. B 879, 3303-3309 (2011).

  4. Substrate stereoselectivity of mammalian D-aspartyl endopeptidase.
    Tadatoshi Kinouchi, Norihiko Fujii and Noriko Fujii. J. Chromatogr. B Analyt Technol Biomed Life Sci. 879, 3349-3352. (2011).

  5. Determination of rate constants for beta-linkage isomerization of three specific aspartyl residues in recombinant human alpha A-crystallin protein by reversed-phase HPLC.
    Yutaka Sadakane, Noriko Fujii, Kazuya Nakagomi . J Chromatogr. B 879, 3240-3246 (2011).

2010

  1. Influence of Lβ-, Dα-, and Dβ-Asp isomers of the Asp-76 residue on the properties of αA-crystallin 70-88 peptide.
    Noriko Fujii, Norihiko Fujii, Masashi Kida and Tadatoshi Kinouchi. Amino Acids 39, 1393-1399 (2010).

  2. Differentiation and Semiquantitative analysis of an isoaspartic acid in human alpha -crystallin by Post Source Decay on Curved Field Reflectron.
    Yuzo Yamazaki, Norihiko Fujii, Yutaka Sadakane and Noriko Fujii. Anal. Chem. 82, 6384－6394 (2010).

  3. The Protective Effects of Metallothionein I and II against Metal- or Ultraviolet Radiation-Induced Damages in Cultured Lens Epithelial Cells.
    Saito T, Tezuka T, Konno R. and Fujii N. Jpn J. Ophthalmol. 54, 486-493 (2010).

  4. Accumulation of D-β-Aspartic acid-containing proteins in age-related ocular diseases.
    Yuichi Kaji, Tetsuro Oshika, Yutaka Takazawa, Masashi Fukayama, Noriko Fujii. Chemistry and Biodiversity 7, 1364-1370 (2010).

  5. SANS and SAXS Observations of Abnormal Aggregation of alpha-Crystallin.
    Masaaki Sugiyama, Norihiko Fujii, Yukio Morimoto, Keiji Itoh, Kazuhiro Mori, Toshiharu Fukunaga, and Noriko Fujii. Chemistry and Biodiversity 7, 1380-1388 (2010).

  6. Influence of oxidative stress on D-aspartyl endopeptidase activity.
    Tadatoshi Kinouchi, Takahiko Shimizu, Takuji Shirasawa and Noriko Fujii. Chemistry and Biodiversity 7, 1398-1402 (2010).

  7. Structural consideration of mammalian D-aspartyl endopeptidase.
    Tadatoshi Kinouchi and Noriko Fujii. Chemistry and Biodiversity 7, 1403-1407 (2010).

  8. Oxidative Stress Indces the Formation of D-Aspartyl Residues in the Elastin Mimic Peptide.
    Kuge K, Kitamura K, Nakaoji K, Hamada K, Fujii N, Saito T. and Fujii N. Chemistry and Biodiversity 7, 1408-1412 (2010).

  9. Genome-wide expression changes in Saccharomyces cerevisiae in response to high-LET ionizing radiation.
    S. Mizukami-Murata, H. Iwahashi, S. Kimura, K. Nojima, Y. Sakurai, T. Saitou, N. Fujii, Y. Murata, S. Suga, K. Kitagawa, K. Tanaka, S. Endo and M. Hoshi Appl. Biochem. Biotechnol. 162, 855-870.(2010).

2009

  1. Localization of D-β-Aspartyl Residue-Containing Proteins in Various Tissues.
    Motoie R, Fujii N,* Tsunoda S, Nagata K, Shimo-oka T, Kinouchi T, Fujii N, Saito T and Ono K. Int. J. Mol. Sci. 10, 1999-2009 (2009).

  2. A Simple and Rapid Method for Measurement of (10)B-para-Boronophenylalanine in the Blood for Boron Neutron Capture Therapy Using Fluorescence Spectrophotometry.
    Kashino G, Fukutani S, Suzuki M, Liu Y, Nagata K, Masunaga S, Maruhashi A, Tanaka H, Sakurai Y, Kinashi Y, Fujii N, Ono K. Radiat Res (Tokyo). 50, 377-382 (2009).

  3. Tryptophanase-Catalyzed l-Tryptophan Synthesis from d-Serine in the Presence of Diammonium Hydrogen Phosphate.
    Shimada A, Ozaki H., Saito T. and Fujii N. Int. J. Mol. Sci. 10, 2578-2590 (2009).

  4. Immunohistochemical localization of D-β-aspartic acid-containing proteins in climatic droplet keratopathy.
    Kaji Y, Oshika T, Takazawa Y, Fukayama M, Fujii N. Br. J. Ophthalmol. 93, 977-979 (2009).

  5. Immunohistochemical localization of D-beta-aspartic acid in pinguecula.
    Kaji Y, Oshika T, Okamoto F, Fujii N. Br J Ophthalmol. 93, 974-976 (2009).

  6. Screening system for D-Asp-containing proteins using D-aspartyl endopeptidase and two-dimensional gel electrophoresis.
    Sakai-Kato K, Kinouchi T, Fujii N, Imai K, Utsunomiya-Tate N. Amino Acids 36, 125-129 (2009).

2008

  1. Study of subunit interactions of alpha A- and alpha B- crystallins and the effects of gamma-irraditation on their interactions by surface plasmon resonance.
    Fujii N. Hisano T. and Fujii N. Biochim. Biophys. Acta 1784, 1507-1513 (2008).

  2. Differential rate constants of racemization of aspartyl and asparaginyl residues in human alpha A-crystallin mutants.
    Nakamura T., Sakai M., Sadakane Y., Haga T., Goto Y., Kinouchi T., Saito T, and Fujii N. Biochim. Biophys. Acta 1784, 1192-1199 (2008).

  3. Structural evolution of human recombinant alpha B-crystallin under UV irradiation.
    Sugiyama M., Fujii N., Morimoto Y., Kurabayashi S., Vigild, M., Sato T., Nakagawa T., Ito K., Mori K. and Fukunaga T. Biomacromolecules 9, 431-434. (2008).

  4. Effects of UV irradiation on ESR and optical properties of Cu(II) ions in organic solid solutions containing CuCl at 77 K.
    Y.M. Hase, Y. Nakano and T. Saito. The Open Magnetic Resonance Journal 1, 81-87. (2008).

2007

  1. Localization of D-beta-aspartic acid-containing proteins in human eyes.
    Kaji Y, Oshika T, Takazawa Y, Fukayama M, Takata T, Fujii N. Invest. Ophthalmol. Vis. Sci. 48, 3923-3927. (2007).

  2. Conformation-dependent racemization of aspartyl residues in peptides.
    Kuge K., Brack A., and Fujii N. Chem. Eur. 13, 5617-5621. (2007).

  3. Shape of alpha-Crystallin Analyzed by Small-Angle Neutron Scattering.
    Masaaki Sugiyama M., Fujii N., Morimoto Y., Otomo T., Takata T., Misawa M, Annaka M., Mori K., Sato T., Kurabayashi S. and Fukunaga T. J. Appl. Crystal. 40, 200-204. (2007).

  4. Age related changes of alpha-crystallin aggregate in human lens.
    Fujii N, Shimmyo Y, Sakai M, Sadakane Y, Nakamura T, Kinouchi T, Morimoto Y, Goto Y and Lampi K. Amino Acids. 32, 87-94. (2007).

  5. Isolation and characterization of mammalian D-aspartyl endopeptidase.
    Kinouchi T, Nishio H, Nishiuchi Y, Tsunemi M, Takada K, Hamamoto T, Kagawa Y, Fujii N. Amino Acids. 32, 79-85. (2007).

  6. Differential susceptibility of alpha A- and alpha B-crystallin to gamma-ray irradiation.
    Fujii N., Nakamura T, Sadakane Y, Saito T, and Fujii N, Biochim. Biophys. Acta. 1774, 345-350. (2007).


Review/Books (English)

  1. ᴅ-amino acid in protein: The mirror of life as a molecular index of aging.
    Noriko Fujii, Takumi Takata, Norihiko Fujii, Kenzo Aki and Hiroaki Sakaue.     Biochimica et Biophysica Acta 1866, 840-847 (2018).
  2. The age related increase of D-amino acids and advanced glycation end-products in protein.
    Noriko Fujii and Takumi Takata. Glycative Stress Research 4, 203-211(2017) ISBN: 2188-3610.
  3. "The Importance of the Idea of“Parachirality” in Life Science.
    Noriko Fujii, Norihiko Fujii, Takumi Takata  and Hiroaki Sakaue. Chapter 6, “ADVANCES IN ASYMMETRIC AUTOCATALYSIS AND RELATED TOPICS (the'Work") edited by Gyula Palyi, Robert Kurdi and Claudia Zucchi (the "Editor”). Chapter 6, pp119-131. Elsevier Inc. (2017) ISBN: 978-0-12-812824-4.
  4. D-Amino acid residues in proteins related to aging and age-related diseases and a new analysis of the isomers in proteins.
    Noriko Fujii, Takumi Takata, Norihiko Fujii, Kenzo Aki and Hiroaki Sakaue. pp 241- 254“D-Amino acids: Physiology, Metabolism, and Application” edited by Yoshimura T, Nishikawa T and Homma H. Springer, (2016) ISBN: 978-4-431-56075-3.
  5. Isomerization of aspartyl residues in crystallins and its influence upon cataract.
    Noriko Fujii, Takumi Takata, Norihiko Fujii , Kenzo Aki. Biochimica et Biophysica Acta 1860,183-191 (2016). 
  6. Quantitative analysis of isomeric (l-α-, l-β-, d-α-, d-β-) aspartyl residues in proteins from elderly donors.
    Noriko Fujii, Takumi Takata, Norihiko Fujii Journal of Pharmaceutical and Biomedical Analysis, 116, 25-33 (2015).
  7. Emerging issues in radiogenic cataracts and cardiovascular disease.
    Hamada N, Fujimichi Y, Iwasaki T, Fujii N, Furuhashi M, Kubo E, Minamino T, Nomura T and Sato H. J. Rad. Res., 1－16 (2014) Review Article.
  8. Non-Enzymatic Post-Translational Modifications in the Development of Age-Related Macular Degeneration. 
    Yuichi Kaji, Tetsuro Oshika and Noriko Fujii. pp 73-82 Chapter 4 in Age Related Macular Degeneration - The Recent Advances in Basic Research and Clinical Care. Edited by Gui-Shuang Ying. InTech, January, 2012, ISBN #978-953-307-864-9.
  9. Analysis of D-β-aspartyl Isomers at Specific Sites in Proteins.
    Noriko Fujii and Norihiko Fujii. Methods in Molecular Biology , Vol. 794 pp325-335 Chapter 22: Unnatural Amino Acids, Pollegioni, Loredano; Servi, Stefano (Eds.) Springer New York, 2012, ISBN 978-1-61779-330-1.
  10. D-amino-acid-containing proteins in living body.
    Noriko Fujii, Kenzo Aki and Norhiko Fujii.  “The Soai Reaction and Related topic” edited by Gyula Pály, Claudia Zucchi, Luciano Caglioti. Accademia Nazionale di Scienze Lettere e Arti Modena, Italy. ISBN 978-88-6462-130-2 Chapter 2, pp35-52 (2012) (Total 376 pages).
  11. Abnormal protein aggregation due to the presence of D-aspartyl residues in cataractous lenses.
    Noriko Fujii, Norihiko Fujii and Masaaki Sugiyama,Trans.Mat.Res.Soc.Japan, 37,131-134 (2012).
  12. D-Amino acids in aged proteins: analysis and biological relevance.
    Noriko Fujii, Yuichi Kaji and Norihiko Fujii. J. Chromatogr. B 879, 3141-3147 (2011).
  13. Pathological Role of D-amino Acid-Containing Proteins and Advanced Glycation End Products in the Development of Age-Related Macular Degeneration.
    Yuichi Kaji, Tetsuro Oshika, Yutaka Takazawa, Masashi Fukayama, Noriko Fujii. Anti-Aging Medicine 7 (10) : 107-111, 2010 review.
  14. Collapse of Homochirality of Amino Acids in Protein from Various Tissues During Aging.
    Noriko Fujii, Yuichi Kaji, Norihiko Fujii, Ryota Motoie, Yuhei Mori and Tadatoshi Kinouchi. Chemistry and Biodiversity 7, 1389-1397 (2010).
  15. Detection of the specific D-aspartic acid residues in protein.
    Fujii N. and Takata T. “D-Amino Acids: A New Frontier in Amino Acid and Protein Rsearch-practical Methods and Protocol”s. edited by Konno R, Bruckner H, D'Aniello, Fujii N and Homma H. Nova Science Publishers, New York pp355-367 (2007).



総説 (日本語)

  1. ヒト水晶体加齢モデル蛋白質の熱安定性とシャペロン様機能の測定
    高田匠、藤井紀子　JASCOレポート 61, 1-6 (2019)
  2. 水晶体内クリスタリン中のアスパラギン酸残基の異性化
    高田匠、藤井紀子　生化学 91, 322-328 (2019)
  3. 老化による蛋白質中のD-アミノ酸生成と加齢性疾患
    藤井紀子　海洋化学研究、31, 84-90 (2018) 
  4. 蛋白質中のD-アミノ酸と老化
    藤井紀子、高田匠、金仁求　臨床免疫・アレルギー科 70, 467-474 (2018)
  5. 水晶体構成蛋白質中におけるアミノ酸の自発的化学修飾が引き起こす白内障発症機構に関する研究
    高田匠　日本白内障学会誌 30, 7-12 (2018)
  6. 生命科学におけるパラキラリティーの重要性
    藤井紀子、高田匠　日本眼薬理 31, 20-27 (2017).
  7. D-アミノ酸含有蛋白質と老化-健康-病態
    藤井紀子　食品加工技術 37, 80-84 (2017).
  8. D-アミノ酸と老化; 新規老化マーカーとしてのD-アミノ酸の有用性
    藤井紀子、高田匠　アンチエイジング医学-日本抗加齢学会雑誌 13, 383-391 (2017).
  9. 白内障と酸化ストレス
    高田匠、金仁求、藤井紀子　OCULISTA 51, 28-34 (2017).
  10. 白内障原因蛋白質の変化をとらえる化学的アプローチ：白内障におけるホモキラリティーの喪失
    藤井紀子、高田匠　日本白内障学会誌 29, 13-20 (2017).
  11. 紫外線による白内障と皮膚老化はアミノ酸の形でわかる
    藤井紀子　環境と健康　特集：紫外線の影響健康ーその功罪を考える 30, 103-110 (2017).
  12. 老化、放射線による水晶体タンパク質中のアミノ酸一残基ごとの翻訳後修飾の解析
    藤井紀子、金仁求、齊藤毅、高田匠　放射線生物研究 52(1), 24-34 (2017).
  13. 加齢によるタンパク質ホモキラリティーの破れ
    藤井紀子、高田匠、坂上弘明、藤井智彦　Viva Origino 44(3), 2 (2016).
  14. 老化で生じる蛋白質中のD-アミノ酸とその分布
    藤井紀子　科学と工業 90, 315-321 (2016).
  15. 白内障の予防と治療を見据えた白内障クリスタリン中の異性体アミノ酸の迅速分析
    藤井紀子、高田匠、藤井智彦、金仁求　日本白内障学会誌 28, 59-62 (2016)
  16. 白内障とクリスタリンの翻訳後修飾
    (Cataract Formation and Age-Dependent Post-Translational Modifications in Crystallin)
    高田匠、藤井紀子　日本白内障学会誌(The Journal of the Japanese Society for Cataract Research)　27, 15-18 (2015)
  17. 光老化科学の最前線
    藤井紀子、高田匠、 前田憲寿監修、CMC出版、第8章　皮膚蛋白質中のアスパラギン酸残基異性体と紫外線による皮膚老化の関連性　pp71-80 (2015)
  18. 放射線、紫外線照射、老化によるタンパク質への影響とその分析
    藤井紀子　CSJ　カレントレビュー17 「極限環境の生体分子―過酷 な環境下での機能を科学する」日本化学会編　化学同人　16章　pp148-156 (2014)
  19. 生物がもつ左手型と右手型のアミノ酸　今後、生物のもつアミノ酸の起源が明らかに？ 
    Newton 別冊（ニュートンムック）やさしくわかる生命の科学,54-55（2014）
  20. D-アスパラギン酸が惹起す るタンパク質の異常凝集と加齢性疾患 
    (Abnormal aggregation of proteins induced by biologically uncommon D-aspartyl residues and age-related diseases) 藤井紀子 Vitamins (Japan), 88 (8), 419-424 (2014)
  21. 白内障水晶体蛋白質中のアスパラギン酸残基の新しい異性体分析法
    藤井智彦、藤井紀子　日本白内障学会誌　26, 33-36 (2014) 
  22. D-アミノ酸を指標とする蛋白質の光老化機構の解明
    藤井紀子　医学のあゆみ、248, 602-607 (2014)
  23. アミノ酸の“利き手問題”とは？ 
    Newton 別冊（ニュートンムック）生命活動を理解するカギ　人体は'なに'で作られているのか　分子レベルの万能素材-タンパク質,76-81（2013）
  24. 身近なD-アミノ酸、その存在と役割　
    藤井紀子　アミノ酸研究、6 , 19-24 (2012)
  25. D-アスパラギン酸の生成によるクリスタリンの機能低下
    藤井　紀子、日本白内障学会誌 24,　5-9　（2012）
  26. 白内障発症機構の解明―タンパク質化学からのアプローチ 
    藤井紀子　、日本白内障学会誌23,　29-32　（2011）
  27. D-アミノ酸と老化の関係 
    藤井紀子　現代化学　466, 42-47 (2010)
  28. 老化とD-アスパラギン酸 
    藤井紀子　　バイオインダストリ-　6-12、27,　（2010）
  29. 老化、紫外線による蛋白質中のアミノ酸のD-化 
    藤井紀子　アニテックス　21,　31-35　（2009）
  30. 中性子散乱で見るタンパク質の異常凝集　（SANS observation of abnormal aggregation of protein） 
    杉山正明、藤井紀子、森本幸生、福永俊晴　日本中性子科学会誌「波紋」18, 191-196（2008）
  31. 眼の加齢性変化におけるAGEとD－アミノ酸の役割 
    加治優一、藤井紀子「　眼科プラクテイス　抗加齢眼科学22」　坪田一男編　文光堂　pp 164-169　　（2008）
  32. 生体内D-アミノ酸研究の新展開 
    藤井紀子、本間浩、実験医学　5月号　Vol 26, No8 1278-1284 (2008)　
  33. 蛋白質の翻訳後修飾がもたらす眼疾患 
    藤井紀子、加治優一「日本の眼科」Vol 79, No3　289-293　(2008) 　
  34. 蛋白質の異常沈着が引きおこす眼疾患　(Ocular diseases related abnormal accumulation of modified proteins)  
    加治優一, 藤井紀子Pharma Media 26, 61-64 (2008)
  35. 老化タンパク質中のD-アミノ酸 
    藤井紀子、加治優一、生化学　80, 287-293（2008）